Intraocular Drug Delivery Systems Gaining Momentum

The era of intraocular drug delivery has started.  A year ago, Allergan began shipping Ozurdex to the private sector.  As with most of these “injections,”  Ozurdex is injected into the vitreous cavity.  Ozurdex releases the steroid dexamethasone for 4-6 months. Ozurdex for Retinal Vein Occlusions and Uveitis The mainstay of treatment for retinal vein occlusions has been … [Read more...]

2010: “Year of the…Drug Delivery System?”

2010 may be the year of drug delivery systems.  Icon Bioscience, Inc., (IBI) has announced their initiation of Phase 2 and Phase 3 clinical trials for an injectable sustained release system for the use in cataract surgery.  Their product, under the code name IBI-10090, will release anti-inflammatory drug for 2-3 weeks after cataract surgery.  It is hoped that this will … [Read more...]

Steroids Likely to Help Diabetes

Ok, maybe a bit dramatic, but another article was recently published stating that intravitreal injections were used with success to treat diabetic macular edema.   These effects lasted at least 5 years, the duration of the study. This was a small study where two groups were compared.  One group received intravitreal injections of triamcinalone (a steroid) for the … [Read more...]

SurModics’ Drug Delivery to Release Lucentis for Macular Degeneration

In a press release this week, Surmodics, Inc., announced its agreement with Roche and Genentech, manufactureres of Lucentis® (ranibizumab), to develop a sustained release drug delivery system for the treatment of wet macular degeneration. Surmodics has a drug delivery system based upon biodegradable microparticles that may potentially reduce the annual number injections … [Read more...]

Intraocular Drug Delivery – It’s About Timing

Ok, maybe a little pun in the title. Yesterday, I wrote about Alimera's study using Iluvien™ for the treatment of diabetic macular edema.  As we have been commonly using intraocular steroid injections to treat this condition (see previous posts under "treatments"), it only makes sense that there are now products (Ozurdex/Allergan and Iluvien/Alimera) that have been … [Read more...]

Company Hopes Injectable Implant Cures Diabetic Macular Edema

Alimera Sciences hopes that its Iluvien ™ insert will be effective against diabetic macular edema.  Iluvien™ will release a steroid called fluocinalone acetonide (FA) after insertion into the eye.  The Iluvien™ system will deliver the steroid for up to 3 years.  It is anticipated that intraocular steroid release may control macular edema and improve vision.  The company … [Read more...]

Steroid Implant May Reduce Diabetic Retinal Edema

In June, the FDA approved a new intraocular device for the treatment of so-called retinal vein occlusions. In this disease, the whole or partial venous tree of the retina becomes occluded. Secondary swelling of the macula occurs thereby reducing vision. Current therapy involves only laser treatment. This new drug delivery system, marketed by Allergan Pharmaceuticals, … [Read more...]

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